In terms of the quality of CBD in CBD Guru CBD isolate and oil, there is no difference. Each one contains CBD derived from organic hemp that has been grown in the United States without the use of chemicals, insecticides, or herbicides. The main difference is in the form of consumption. You can hold CBD oil beneath the tongue for up to 90 seconds and swallow, or add it to your food or a drink. CBD isolate is more convenient for some users because it is tasteless, it can be added to practically any food or drink type.