What is CBG?

CBG: More Than Just Another Cannabinoid!



When it comes to cannabinoids, THC and CBD are the stars of the cannabis and hemp narrative. The many non-psychoactive and supplemental benefits of CBD continue to dominate the natural health and wellness industry. However, there is another cannabinoid, CBG that has recently turned up on the hemp industry radar. 


What is CBG?


CBG (cannabigerol) is a cannabinoid that could be called the ‘mother’ of the three main branches of cannabinoids: THCA, CBDA and CBCA. CBGA is a precursor to these three main cannabinoids found in the cannabis and hemp plant. A precursor, in biochemistry, is a substance from which another is formed, especially by metabolic action.


Researchers discovered cannabigerolic acid, or CBGA, in 1975. CBGA is the first cannabinoid formed in the plant, the first expression of cannabinoids. From that first expression, CBGA is transformed into the three main cannabinoid lines, THCA, CBDA or CBCA by the action of enzymes. It is this ability to produce cannabigerolic acid orCBGA that makes the cannabis and hemp plant unique.


Specific natural enzymes of the plant, called synthase, break down the CBGA and direct it towards the three main cannabinoid lines. The plant’s synthases, THC-synthase, CBD-synthase and CBC-synthase, are named after the cannabinoid they help to create. Then when the acids of CBGA become exposed to ultraviolet light or heat they morph into the cannabinoids THC and CBD.


CBG from Hemp VS Cannabis


It has been discovered that hemp strains contain much higher levels of CBG than strains of cannabis. Some studies show that this phenomenon may be due to a recessive gene in the hemp plant. So far, the study indicates that the gene maintains the production in the plant of one of the cannabinoid synthases, which converts the CBGA to one of the main branches. 


Certain strains of European hemp, which produce high CBD, can carry this recessive gene or genetic mutation that causes the CBD-gene to become inactive: thus the plant accumulates cannabigerol (CBG) instead of CBD. This has been shown to be a recessive trait by botanists, however; it is still possible to harness CBG-producing genetics from hemp for CBG supplements.



CBG and the Endocannabinoid System


In the early 1990’s it became known, through research, that both humans and animals have an Endocannabinoid System (ECS). The ECS regulates all body functions, including nerves, digestion and sleep. The ECS is the body’s largest receptor system and it’s ultimate goal is maintaining homeostasis, or balance.

There are two main types of receptors: CB1 and CB2. CB1 receptors are found mostly in the brain and in organs. CB2 receptors live on cells.


This system requires Omega Fatty acids in a particular ratio to produce and uptake it’s own cannabinoids. Because of the nutritional downgrade of today’s food and diet, there is a deficiency of Omega-3’s in most people. This, in turn, creates an endocannabinoid deficiency, resulting in unrest, imbalance and disease. 


When a cannabinoid, such as CBG, is introduced into the body it acts upon the receptors. What is known, so far, about CBG is that it is an antagonist of the CB1-receptor, which affects the central nervous system. CBG has also been shown to affect the CB2-receptor, which influences the body to a greater degree. However, it has not been determined by researchers, yet, whether CBG promotes or inhibits CB2-receptor activity. 



The Medicinal and Supplemental properties of CBG


The benefits and value of supplementing with CBG, according to current research, is directly related to what is known about the receptor activity in the ECS. This receptor activity is what creates the properties and effects of CBG in the body.

These include:


Reduction of intraocular pressure (eye-as in Glaucoma)

Antibiotic and antibacterial effect 

Prevention of colon carcinogenesis

Anti inflammatory in the digestive system

Analgesic (pain relief)


Neuroprotective properties

Antiseptic properties 

Inhibits the uptake of GABA (as in anxiety, muscle tension)

Stimulates appetite

Stimulates bone formation

Antispasmodic effect 



Considering the fact that CBGA is the precursor to the main three branches of cannabinoids THC, CBD and CBC: it stands to reason that it also enhances the effectiveness of each of those cannabinoids. When CBG is used along with other cannabinoids and terpenesthe effectiveness is further enhanced and it is called, the entourage effect. The introduction of CBG as a supplement along withsupplementing CBD, only, has been shown to provide powerful support to the homeostasis of the body.



Scientific Studies On CBG and CBGA


Since CBG is becoming a cannabinoid of interest in the health and wellness industry, scientific research on its benefits is increasing. Here are some interesting scientific studies that have been conducted on various possible benefits for various conditions.


Inflammatory Bowl Disease


Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease.







A Comparison of the Ocular and Central Effects of  Δ9-Tetrahydrocannabinol and Cannabigerol





Appetite Stimulant (in Rats)


CBG Cannabigerol is a Novel, Well Tolerated Appetite Stimulant in Pre-Satiated Rats






In European research it has been shown that CBG is an effective antibacterial agent. It has been shown to be particularly effective against methicillin-resistant Staphylococcus aureus (MRSA) microbial strains resistant to drugs.





CBG Oil as a Supplement


Adding CBG Oil to your daily supplement regime, either alone or in conjunction with CBD Oil can provide an enhanced supplemental effect. The fact that CBGA is the precursor, or as some refer to it, the ‘stem-cell’, of the primary cannabinoids is an indication of its importance in the creation of other cannabinoids and in homeostasis. The goal of all supplements is to bring the body to a balanced state of optimal health. CBG, as a non-psychoactive, non-toxic supplement is quickly becoming a cannabinoid of increasing interest to scientists and consumers, alike. 


Through further research and clinical studies, more areas of human health might be shown to benefit with daily use of CBG Oil. We are in exciting times of discovery with respect to this ancient plant. CBG is being tried and tested both in scientific laboratories as well as the laboratory of human experience. So far, the results are creating excitement and show that CBG is more than just another cannabinoid.

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